Muvalaplin, an oral, once-daily treatment that inhibits lipoprotein(a) formation via a novel mechanism, achieved positive results in a 12-week Phase 2 study. These data were publi ...

The placebo-adjusted reductions were up to 85.8% using an intact Lp(a) assay and up to 70.0% using an apo(a) assay. Specifically, the reductions were 47.6% at 10 mg, 81.7% at 60 mg and 85.8% at 240 mg ...

One is an siRNA biologic, the other an oral agent, but both lowered Lp(a) levels by 80% or more in ASCVD patients.

50% LDL-C reduction from baseline and the new lower LDL-C target of < 55 mg/dL for those with, or at very hisk for, CVD Lerodalcibep reduced mean Apo B by 45% and median Lp(a) by 30-32% Lerodalcibep ...

A clinical trial testing muvalaplin, a novel oral medication, was able to safely and effectively lower high levels of lipoprotein (a), according to late-breaking science presented today at the ...