The San Francisco 49ers activated running back Christian McCaffrey from the Injured Reserve list and safety Tashaun Gipson Sr. from the team's practice squad.

The San Francisco 49ers recently brought a familiar face back onto their practice squad. Now they may need to turn to that ...

Spending the first half of the season as a spectator while he worked his way back from Achilles tendinitis took its toll on ...

The Tampa Bay Buccaneers and the San Francisco 49ers are set to face off as the Bucs face their second Super Bowl team in as ...

The San Francisco 49ers entered the season as the betting favorite to win the Super Bowl. After all, they were coming off an appearance in the ...

The San Francisco 49ers offense knows they’re in for a tough matchup against Tampa Bay Buccaneers pass rusher Vita Vea.

Before Week 10 of the NFL season kicks off, check out Tom Brady's latest Power Rankings to see who made the GOAT's top five ...

Six teams are road favorites and two more are slight underdogs in Week 10. The 49ers, Bills, Vikings, Falcons, Eagles and ...

Traditional NFC West powers San Francisco, Seattle and the Los Angeles Rams are facing an unforeseen challenge from the ...