Key influenza-severity risk factor found hiding in plain sight on our antibodies
Viruses are the fastest-evolving biological entity on Earth. This fact explains why we need flu shots every year: Seasonal ...
Savara Reports Third Quarter 2024 Financial Results and Provides Business Update
Savara Inc. (Nasdaq: SVRA) (the Company), a clinical stage biopharmaceutical company focused on rare respiratory diseases, reported financial results for the third ...
FiercePharma25d
Savara sponsors Lifetime talk show episode about rare respiratory disease ahead of FDA submission
Pulmonary alveolar proteinosis is caused by a buildup in the lungs’ alveoli of a substance called surfactant that’s made up of proteins and lipids. The buildup can block air from moving ...
Business Wire25d
Savara Announces the Rare Lung Disease, Autoimmune Pulmonary Alveolar Proteinosis (aPAP), is Highlighted on a New Episode of “The Balancing Act ® ” Airing on Lifetime ® TV
In a healthy lung, excess surfactant is cleared and digested by immune cells called alveolar macrophages. Alveolar macrophages need to be stimulated by granulocyte-macrophage colony-stimulating ...
Frontiers26d
Editorial: Endocytic and trafficking events in acute lung injury and pulmonary inflammation
Hence, disturbances in endocytosis and trafficking across and within alveolar epithelial and endothelial cells are important drivers of alveolar-capillary barrier dysfunction during respiratory ...
Medscape1mon
Mechanisms of Acute Respiratory Distress Syndrome in Children and Adults
The pathophysiology of acute respiratory distress syndrome is divided into eight categories: alveolar fluid transport, surfactant, innate immunity, apoptosis, coagulation, direct alveolar ...
eLife1mon
β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
The work will be of high interest to both researchers in the trained immunity field and clinician scientists. Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung ...
eLife1mon
β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different ...
Business Wire1mon
Savara Announces Expanded Access Program (EAP) for Molgramostim Inhalation Solution (Molgramostim) for Patients with Autoimmune Pulmonary Alveolar Proteinosis (aPAP)
In a healthy lung, excess surfactant is cleared and digested by immune cells called alveolar macrophages. Alveolar macrophages need to be stimulated by granulocyte-macrophage colony-stimulating ...
Medscape1mon
Mechanisms of Acute Respiratory Distress Syndrome in Children and Adults
Future studies of the effect of exogenous surfactant in children and adults ... the determination of differences between the degree of alveolar epithelial injury, inflammatory and innate immune ...
Nature1mon
Developmental Cell/Molecular Biologic Approach to the Etiology and Treatment of Bronchopulmonary Dysplasia
and the retrograde stimulation of alveolar type II cell surfactant phospholipid and protein synthesis by leptin. Each of these paracrine interactions requires cell-specific receptors on adjacent ...