Eli Lilly and Company (NYSE: LLY) today announced positive Phase 2 results for muvalaplin, an investigational once-daily, orally administered selective inhibitor of lipoprotein(a) [Lp(a)], a ...

The placebo-adjusted reductions were up to 85.8% using an intact Lp(a) assay and up to 70.0% using an apo(a) assay. Specifically, the reductions were 47.6% at 10 mg, 81.7% at 60 mg and 85.8% at 240 mg ...

One is an siRNA biologic, the other an oral agent, but both lowered Lp(a) levels by 80% or more in ASCVD patients.

Muvalaplin works, Nicholls explained at the press briefing, by disrupting the bonding of apo(a) to apoB, which does not allow Lp(a) to form. The study examined 3 different doses, at 10 mg, 60 mg, and ...

This would suggest that the previously reported inverse relationships of HDL-C and apo A-I with CAD do not hold ... However, at very high levels of HDL-C (≥70 mg/dL), this inverse relationship ...

Muvalaplin shows promise in lowering lipoprotein(a) levels, which are genetically determined and confer cardiovascular risk ...

50% LDL-C reduction from baseline and the new lower LDL-C target of < 55 mg/dL for those with, or at very hisk for, CVD Lerodalcibep reduced mean Apo B by 45% and median Lp(a) by 30-32% Lerodalcibep ...

1 Day APO -10.78% DJIA 0.11% S&P Mid Cap 400 -0.53% Business/Consumer Services 0.31% ...

This particular genetic type of leukemia is present in approximately 10% of cases, and is difficult to treat, leading to high ...

A clinical trial testing muvalaplin, a novel oral medication, was able to safely and effectively lower high levels of lipoprotein (a), according to late-breaking science presented today at the ...

Verdict – is the MG HS a good car? The latest MG HS represents a huge improvement over its predecessor, offering extra practicality, a nicer interior and a very competitive 75-mile range for the ...