This leads to ribosome production arrest and a potentially alternative way p14 ARF elicits its tumor suppressor function.

Ribosomal RNA also performs the most crucial and ancient function inside ribosomes: the fascinatingly efficient translation of mRNA into protein. The very first proteins must have been made by ...

There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied ...

November 11, 2024) There are processes in the human body that can suppress the growth and proliferation of cancer cells.

which support basic ribosomal functions, and interacts with the Gcn2 kinase, linking the ribosomes to the ISR pathway. We show that P-stalk proteins, which form a pentamer, exist in the cell ...

Transcriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the ...

We identified novel variants in ribosomal protein S6 kinase beta-1 (RPS6KB1 or S6K1 ... the rpS6 and ERK1/2 signalling cascades, suggesting a gain-of-function effect. Contributors PSD conceived, ...

Depletion of eIF3e and partially eIF3d also increased translation of TOP mRNAs that encode mainly ribosomal proteins and other components of ... empirical cumulative distribution functions (ECDFs) of ...

In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) ...

In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...