Anatomy, Back, Nucleus Pulposus - StatPearls - NCBI Bookshelf
Aug 7, 2023 · Structure and Function. The makeup of the nucleus pulposus allows it to play an essential role in the flexibility and stability of the spine. It is made up of water, type II collagen, chondrocyte-like cells, and proteoglycans (sulfated glycosaminoglycans).
Nucleus Pulposus - an overview | ScienceDirect Topics
The nucleus pulposus is the soft, gelatinous central portion of the intervertebral disk that moves within the disk with changes in posture. It plays a crucial role in maintaining the structure and function of the spinal disk by resisting compression through its proteoglycan composition.
Nucleus Pulposus - an overview | ScienceDirect Topics
Nucleus pulposus mechanics. The nucleus pulposus is a highly hydrated gel with important material properties that include swelling pressure, compression modulus, permeability, and shear modulus. The nucleus has a large water and proteoglycan content.
Serglycin secreted by late-stage nucleus pulposus cells is a
Jan 2, 2024 · We identify fibrotic late-stage nucleus pulposus cells characterized by upregulation of serglycin expression which facilitate the local inflammatory response by promoting the infiltration of...
Expansion of FGFR3-positive nucleus pulposus cells plays …
IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferative potential and regenerative ability. ... Intervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern.
Single-cell sequencing reveals cellular heterogeneity of nucleus ...
Nov 8, 2024 · Single-cell transcriptomic profiling of human nucleus pulposus (NP) with IVDD. (A) UMAP visualization of human NPCs identified eight different clusters.Each dot corresponds to a colored cell ...
Notochordal and nucleus pulposus marker expression is ... - Nature
May 4, 2017 · The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial changes in cell and matrix composition with both ageing and degeneration. While recent transcriptomic...
Cell sources proposed for nucleus pulposus regeneration - PMC
As nucleus pulposus (NP) degeneration is thought to represent a key initiation site of IVD degeneration, cell therapy that specifically targets the restoration of the NP has been reviewed here. A literature search to quantitatively assess all cell types used in …
Nucleus Pulposus - an overview | ScienceDirect Topics
The nucleus pulposus (NP) is a rounded region located within the center of the IVD (see Fig. 2-12). The NP is thickest from superior to inferior in the lumbar region, followed in thickness by the cervical region; it is the thinnest in the thoracic region.
Characterization of the Nucleus Pulposus Progenitor Cells via …
Feb 4, 2024 · Loss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence of NP cell differentiation remains unclear, although an increasing body of literature has identified markers of NP progenitor cells (NPPCs).