Engineered model of heart tissue repair for exploring fibrotic ...
Sep 12, 2024 · This engineered heart tissue repair model effectively captures the phased remodeling following myocardial infarction, providing a crucial platform for discovering …
Versatile human cardiac tissues engineered with perfusable heart ...
Mar 22, 2024 · In this study, we advanced the development of human cardiac tissues utilizing a bioengineering platform that fully integrates three heart microenvironmental cues: extracellular …
Engineered heart tissue models from hiPSC-derived ... - PubMed
Jul 1, 2019 · Cardiac tissue engineering provides unique opportunities for cardiovascular disease modeling, drug testing, and regenerative medicine applications. To recapitulate human heart …
Engineered human cardiac tissues for modeling heart diseases
These cardiac models have improved heart disease modeling and toxicological evaluation. In this review, we summarize the cell types for the fabrication of cardiac tissue models, introduce …
Engineered Heart Tissue - an overview | ScienceDirect Topics
The increasing population of patients with heart disease, and the limited availability of transplant organs, motivates the field of cardiac tissue-engineering, which aims to generate robust tissue …
Human engineered cardiac tissues - Wikipedia
Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human embryonic stem cells (hESCs) and, more recently, …
Engineered heart tissue: Design considerations and the state of …
Jun 20, 2024 · Originally developed more than 20 years ago, engineered heart tissue (EHT) has become an important tool in cardiovascular research for applications such as disease …
Cardiac tissue engineering: current state-of-the-art materials, …
The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue …
Generating ring-shaped engineered heart tissues from ventricular …
Jan 7, 2020 · Here, the authors create chamber-specific human pluripotent stem cell-derived cardiomyocytes to form both ventricular and atrial cells before embedding in collagen-based …
Opportunities and challenges in cardiac tissue engineering from …
Apr 27, 2022 · Engineered human cardiac tissues facilitate progress in regenerative medicine, disease modelling and drug development. In this Perspective, we reflect on the most notable …